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eravacycline

Pronunciation: ER a va SYE kleen

Brand: Xerava

What is the most important information I should know about eravacycline?

You should not use this medicine if you are allergic to any tetracycline antibiotic.

Using eravacycline during pregnancy may affect tooth and bone development in the unborn baby.

Eravacycline is not approved for use by anyone younger than 18 years old. Eravacycline can cause permanent yellowing or graying of the teeth in children.

What is eravacycline?

Eravacycline is a tetracycline antibiotic that fights bacteria in the body.

Eravacycline is used to treat serious stomach infections in adults.

Eravacycline may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using eravacycline?

You should not use this medicine if you are allergic to eravacycline or other tetracycline antibiotics such as demeclocycline, doxycycline, minocycline, tetracycline, or tigecycline.

Tell your doctor if you have ever had:

  • liver disease.

Using eravacycline during the second or third trimester of pregnancy may affect tooth and bone development in the unborn baby. This could cause permanent tooth discoloration later in the baby's life.

Eravacycline can pass into breast milk and may affect bone and tooth development in a nursing infant. Do not breast-feed while you are using eravacycline, and for at least 4 days after your last dose.

Eravacycline is not approved for use by anyone younger than 18 years old. Eravacycline can cause permanent yellowing or graying of the teeth in children.

How should I use eravacycline?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Eravacycline is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use eravacycline if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Eravacycline must be given slowly, and the infusion can take at least 1 hour to complete.

Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Eravacycline will not treat a viral infection such as the flu or a common cold.

Store unmixed eravacycline powder in the refrigerator, do not freeze.

Mixed eravacycline must be used within 6 hours if you keep it at room temperature, or 24 hours if kept in a refrigerator. Do not freeze.

Each single-use vial (bottle) of this medicine is for one use only. Throw it away after one use, even if there is still medicine left inside.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using eravacycline?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Eravacycline could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of eravacycline?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (may occur up to 2 months after your last dose of eravacycline);
  • severe headaches, dizziness, ringing in your ears, vision problems;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting; or
  • signs of a fungal infection --skin itching or crusting, white patches in your mouth, vaginal itching or discharge, problems with your fingernails or toenails.

Common side effects may include:

  • nausea, vomiting; or
  • pain, bruising, redness, swelling, burning, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect eravacycline?

Tell your doctor about all your other medicines, especially:

  • enzalutamide;
  • mitotane;
  • rifampin;
  • St. John's wort; or
  • a blood thinner --warfarin, Coumadin, Jantoven; or
  • seizure medicine --carbamazepine, phenytoin.

This list is not complete. Other drugs may affect eravacycline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about eravacycline.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 1.01. Revision date: 10/15/2018.

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