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Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.

tedizolid (oral/injection)

Pronunciation: te DIZ oh lid

Brand: Sivextro

What is the most important information I should know about tedizolid?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is tedizolid?

Tedizolid is an antibiotic that is used to treat skin infections in adults, including "MRSA" staph infections.

Tedizolid may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using tedizolid?

You should not use tedizolid if you are allergic to it.

Tell your doctor if you have recently been sick with diarrhea, a fever, cold or flu symptoms, cough, or sore throat.

Tell your doctor if you have ever had diarrhea while taking antibiotics.

Tell your doctor if you are pregnant or breastfeeding.

Tedizolid is not approved for use by anyone younger than 18 years old.

How should I use tedizolid?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tedizolid oral is taken by mouth. Take this medicine at the same time each day, with or without food.

Tedizolid injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. The injection must be given slowly, and the infusion can take at least 1 hour to complete.

Tedizolid injection must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine. Use only the diluent provided with your medicine.

Gently swirl but do not shake the mixed medicine. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use tedizolid for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Tedizolid will not treat a viral infection such as the flu or a common cold.

Store tedizolid tablets at room temperature away from moisture and heat.

Keep each tablet in its blister pack until you are ready to take it. Prepare your tedizolid injection dose only when you are ready to give an injection.

After mixing tedizolid injection, you may store the mixture for up to 24 hours at room temperature or in a refrigerator.

Each single-use vial (bottle) of tedizolid injection is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 8 hours. Do not use two doses at one time. Even if you skip a dose, keep taking the medicine each day until it is gone.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tedizolid?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What are the possible side effects of tedizolid?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • numbness or tingling;
  • vision problems, severe headache or pain behind your eyes;
  • sores or white patches in your mouth or on your skin;
  • vaginal itching or discharge;
  • fast or pounding heartbeats; or
  • low blood cell counts --fever, chills, tiredness, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • nausea, vomiting, diarrhea;
  • headache;
  • dizziness; or
  • pain, swelling, bruising, redness, or a hard lump where a tedizolid injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect tedizolid?

Tell your doctor about all your other medicines, especially:

  • methotrexate;
  • rosuvastatin (Crestor); or
  • topotecan.

This list is not complete. Other drugs may affect tedizolid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about tedizolid.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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